Vincristine Side Effects

Some of the possible side effects of vincristine include diarrhea, headaches, and nausea. A majority of people who use this drug will develop some type of reaction. This prescription chemotherapy product is also associated with potentially serious problems, such dangerous infections, liver problems, and allergic reactions. If you develop anything like this, seek immediate medical treatment.


An Introduction to Side Effects of Vincristine

Just like any medicine, vincristine sulfate (Vincasar PFS®) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some side effects can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with vincristine. Your healthcare provider can discuss a more complete list with you.)

Serious Vincristine Side Effects

Some side effects of vincristine are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Persistent or severe constipation
  • Abdominal (stomach) pain, cramping, fullness, or bloating
  • Feelings of numbness, tingling, pain, burning, or other unusual sensations of the hands or feet
  • Changes in how sensitive your skin is to touch, heat, cold, or pain
  • Muscle weakness or spasms
  • Difficulty moving, walking, speaking, or holding things with your hands
  • Problems with balance
  • Slapping or drooping of the front part of the foot when walking
  • Decreased reflexes
  • Pain in your jaw, face, or head
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Dark urine
    • Pale stool
    • Upper-right abdominal (stomach) pain
  • Sores in the mouth or throat
  • A change in how much or how often you urinate
  • Painful urination
  • Chest pain
  • Shortness of breath
  • Weight loss
  • A change in your vision or hearing
  • Seizures
  • Signs of anemia, such as:
    • Unusual tiredness
    • Weakness
    • Pale skin
    • Shortness of breath
  • Unusual bleeding or bruising
  • Pain, redness, or burning at the injection site
  • Dizziness, faintness, or a spinning sensation
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing.
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Vincristine Drug Information

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