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Treanda Side Effects
Significant and severe side effects may occur with Treanda, so contact your healthcare provider immediately if you develop something that does not seem right. Some of the serious reactions that may occur include anemia, infections, and liver problems. In addition, clinical studies have shown that reduced blood cell counts, nausea, and fatigue were some of the most commonly reported problems with this drug.
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Just like any medicine, Treanda® (bendamustine) can cause side effects. As with other chemotherapy medicines, the side effects can be significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with Treanda. Your healthcare provider can discuss a more complete list with you.)
Treanda has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given Treanda were carefully documented and, in some studies, compared to the side effects that occurred in a similar group of people given a different medication. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the other medicine.
In clinical studies, the most common Treanda side effects included:
- A decrease in lymphocytes (a type of white blood cell) -- in up to 99 percent of people
- A decrease in leukocytes (a type of white blood cell) -- up to 94 percent
- A decrease in hemoglobin (a protein in blood that carries oxygen) -- up to 88 percent
- A decrease in neutrophils (a type of white blood cell) -- up to 86 percent
- A decrease in platelets, which could cause abnormal bruising and bleeding (see Blood Clotting Problems and Chemotherapy) -- up to 86 percent
- Nausea -- up to 75 percent
- Fatigue -- up to 57 percent
- Vomiting -- up to 40 percent
- Diarrhea -- up to 37 percent
- Fever -- up to 34 percent
- Constipation -- up to 29 percent
- Decreased or loss of appetite -- up to 23 percent.
Other common reactions, occurring in 5 percent to 22 percent of people, included:
- Cough
- Headache
- Weight loss
- Shortness of breath
- Rash
- Mouth swelling, irritation, or sores
- Chills
- Dizziness
- Back pain
- Dehydration
- Swelling of the arms, hands, legs, ankles, or feet
- Abdominal (stomach) pain
- Insomnia
- Weakness
- Indigestion
- Heartburn
- Shingles (herpes zoster)
- Upper respiratory tract infection, such as the common cold
- Urinary tract infection (UTI, such as a bladder infection)
- Dry mouth
- A stuffy nose
- Low levels of potassium in the blood (hypokalemia)
- Sore throat
- Anxiety
- Pneumonia
- Increased levels of uric acid in the blood, which could cause gout
- Fast heart rate (tachycardia)
- An abnormal taste in the mouth
- Any infection
- Joint pain
- Thrush (a yeast infection in the mouth)
- Chest pain
- Depression
- Pain at the infusion site (the site where the needle enters the vein)
- Any pain
- Itching
- Low blood pressure (hypotension)
- Abdominal (stomach) swelling
- Dry skin
- Excessive sweating
- Night sweats
- Wheezing
- Arm or leg pain
- Bone pain
- Cold sores.
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD