Your dosage of Tasigna will depend on whether you develop side effects with this drug, other medications you are taking, and other existing medical conditions you have. The medicine comes in capsule form and is taken twice a day, with 12 hours between doses. Do not take Tasigna with food, as this can increase your risk for serious side effects.
The dosage of Tasigna® (nilotinib) your healthcare provider recommends will vary, depending on a number of factors, including:
- Whether you have been previously treated for leukemia
- Whether you experience side effects
- Other medical conditions you may have
- Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
The standard dose of Tasigna for people who are newly diagnosed with chronic myeloid leukemia (CML) in the chronic phase (the beginning stage) is 300 mg twice daily. The standard dosage for people with chronic or accelerated phase CML who are no longer benefiting from or cannot tolerate imatinib (Gleevec®), another leukemia medicine, is 400 mg twice daily.
People with liver disease who are newly diagnosed with CML are usually started on Tasigna 200 mg twice daily and increased to 300 mg twice daily if the medication is tolerated. People with liver disease who cannot tolerate imatinib are usually started on Tasigna 200 mg (for mild-to-moderate liver disease) or 300 mg twice daily (for severe liver disease), and increased to the standard dosage of 400 mg twice daily if tolerated.
People who experience certain Tasigna side effects, such as abnormally low blood cell counts, may need to temporarily stop taking the medicine until the side effects resolve. Tasigna may then be restarted at the same dose or a lower dose. In some cases, once-daily dosing may be recommended. Also, people who take certain other medications may be given lower Tasigna doses (see Tasigna Drug Interactions).