Because the prescribed dosage of Tabloid can vary significantly for each person, your healthcare provider will need to consider your height and weight, how you respond to the drug, and other medications you are taking, among other factors. This chemotherapy drug comes as a tablet that is taken once or twice daily. It should be taken on an empty stomach.
The dose of Tabloid® (thioguanine) your healthcare provider recommends will vary, depending on a number of factors, such as:
- Your weight and possibly your height
- How you respond to and tolerate the medication
- Other medical conditions you may have
- Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Tabloid doses are highly individualized, and can vary significantly from person to person. When used alone and not in combination with other leukemia medicines, the usual recommended dosage is Tabloid 2 mg per kg body weight (about 0.91 mg per lb) per day, rounded to the nearest 20 mg. If no improvement is seen within 4 weeks, the dose may be increased to 3 mg per kg each day (about 1.36 mg per lb).
However, Tabloid is normally used in combination with other medicines. If you are taking Tabloid with other medicines, your healthcare provider will recommend the best dosage and dosing schedule for your particular situation. The amount may be calculated based on your weight or your body surface area, which is determined using your height and weight.
People with a certain inherited (genetic) condition known as thiopurine-S-methyltransferase (TPMT) deficiency are especially sensitive to bone marrow suppression from Tabloid and will, therefore, need lower Tabloid doses. Your healthcare provider may choose to test you for a TPMT deficiency. In addition, people with liver or kidney disease may be treated with lower doses.
Your healthcare provider may temporarily stop treatment or recommend a lower dosage if you develop potentially serious side effects during treatment. In certain cases, such as if you develop serious liver problems, you may need to stop Tabloid treatment altogether.