Synribo Side Effects

If you are receiving chemotherapy treatment with Synribo and experience fever, blood in the urine, or chest pain, contact your healthcare provider right away. Dangerous problems can occur with this prescription drug, so it is important to know which reactions require urgent medical treatment. Other possible side effects of Synribo include nausea, fatigue, and diarrhea.


An Introduction to Synribo Side Effects

As with any chemotherapy medicine, Synribo™ (omacetaxine mepesuccinate) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some problems can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with Synribo. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Synribo

Synribo has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common Synribo side effects included:
  • A low number of platelets in the blood (see Blood Clotting Problems and Chemotherapy) -- in up to 74 percent of people
  • Anemia (see Chemotherapy and Anemia) -- up to 61 percent
  • An infection of any kind, including bacterial, viral, and fungal infections -- up to 56 percent
  • A low level of neutrophils (a type of white blood cell) in the blood (see Chemotherapy and Infections) -- up to 50 percent
  • Diarrhea -- up to 42 percent
  • Reactions at the injection site, such as redness, pain, or irritation -- up to 34 percent
  • Nausea (see Chemotherapy and Nausea) -- up to 32 percent
  • Fatigue -- up to 31 percent
  • Fever -- up to 29 percent
  • Loss of strength and energy -- up to 24 percent.
Other common reactions, occurring in 10 percent to 19 percent of people, included:
  • Joint pain
  • Headache
  • A low level of lymphocytes (another type of white blood cell)
  • Cough
  • Nosebleeds
  • Hair loss (see Chemotherapy and Hair Loss)
  • Constipation
  • Vomiting
  • Upper abdominal (stomach) pain
  • Chills
  • Swelling of the arms, hands, legs, and feet
  • Arm and leg pain
  • Loss of appetite
  • Back pain
  • Shortness of breath
  • Insomnia
  • Rash
  • Bone marrow failure (an inability of the bone marrow to make blood cells).
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Synribo Chemotherapy Information

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