Synribo Dosage

Synribo is a chemotherapy drug that is given as an injection just under the skin (subcutaneously). The recommended Synribo dosage will depend on how much you weigh, your height, how you respond to the medicine, and other factors. Your healthcare provider will administer the injections twice a day for 7 to 14 days, followed by a break in treatment.

An Introduction to Dosing With Synribo

The dose of Synribo™ (omacetaxine mepesuccinate) your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your height and weight
  • How you respond to the medication
  • How well you tolerate it, such as if you experience certain side effects.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

What Is the Recommended Synribo Dosage?

Like many chemotherapy medicines, Synribo doses are based on body surface area, which is calculated using your height and weight. Doses based on body surface area are written as milligrams per meter squared (mg per m2).
The usual recommended initial dosage (called the induction dosage) of Synribo for the treatment of chronic myeloid leukemia is 1.25 mg per m2 twice a day for 14 days in a row. This is called one treatment cycle.
Treatment cycles will normally be repeated every 28 days until blood cell counts have returned to normal, which is known as a hematologic response. Once a hematologic response is achieved, maintenance dosing may begin.
The usual recommended maintenance dose of Synribo is 1.25 mg per m2 twice a day for seven days in a row. This seven-day treatment cycle will be repeated every 28 days as long as you are benefiting from treatment.  
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Synribo Chemotherapy Information

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