Sprycel Drug Interactions

Antacids, cyclosporine, echinacea, and certain other drugs may cause negative interactions when taken with Sprycel. Some of these reactions can increase the risk for side effects or decrease the effectiveness of the medicines. If you are undergoing Sprycel treatment, your healthcare provider may need to monitor you more closely and adjust your dosages as needed.

An Overview of Interactions With Sprycel

Sprycel® (dasatinib) may react with a number of other medications. Some of the drugs that can lead to interactions with Sprycel include but are not limited to:
 
  • Antacids (Gaviscon®, Maalox®, Mylanta®, Tums®, and many others)
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
 
 
 
 
 
  • Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of such medications)
  • Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs), such as:
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
 
 
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Sprycel Medication Information

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