Rituxan Side Effects

Side Effects to Report

Some side effects with Rituxan, although occurring infrequently, are potentially serious -- even life-threatening -- and should be reported to your healthcare provider. These include but are not limited to:
  • Anything that seems unusual, unpleasant, or just "not right" during your Rituxan infusion, as this may be a sign of an infusion reaction
  • A rash of any sort -- in rare cases, this drug can cause serious skin reactions
  • Signs or symptoms of progressive multifocal leukoencephalopathy (PML), such as:
    • Headaches
    • Coordination problems
    • Speech difficulties
    • Memory loss
  • Signs of a tear (perforation) of the stomach or intestines, such as:
    • A sudden change in bowel habits
    • Fever
    • Stomach pain
  • Symptoms of an infection, such as a cough, chills, fever, or weakness
  • An irregular heart rhythm (arrhythmia)
  • Decreased urine production, which may be a sign of kidney damage
  • Severe abdominal pain (stomach pain), constipation, or vomiting, which may be signs of a bowel obstruction.
Infusion reactions are common with Rituxan. However, appropriate "premedication" can help limit the chance and severity of this. Premedication often includes acetaminophen (Tylenol®), an antihistamine, and a steroid. Infusion reactions can range from mild to fatal, and may include the following symptoms:
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Rituxan Medication Information

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