Mustargen and Pregnancy

Dangerous complications may occur while undergoing chemotherapy treatment with Mustargen (mechlorethamine) during pregnancy. Women who are receiving this drug should be aware that this pregnancy Category D medication has been reported to cause miscarriages, birth defects, and other problems when used during pregnancy. This medicine should only be given to a pregnant woman if the benefits to the mother outweigh the risks to the fetus.

Can Pregnant Women Receive Mustargen?

Mustargen® (mechlorethamine) is a prescription chemotherapy medicine used to treat several types of cancer. Mustargen is a pregnancy Category D medicine, meaning it may harm an unborn child if used during pregnancy.
 

What Is Pregnancy Category D?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category D is a classification given to medicines that have been shown to present a risk to the fetus in studies of pregnant women but may still offer benefits that outweigh the risks the drug presents. A pregnancy Category D medicine may still be given to a pregnant woman if her healthcare provider believes that the benefits to the woman outweigh the possible risks to her unborn child.
 
In animal studies, Mustargen caused birth defects when given to pregnant rats and ferrets. These defects occurred after a single dose was given.
 
This drug has not been adequately studied in pregnant women. The medication has been used in women who are pregnant without causing any problems. However, there have also been reports of birth defects occurring when Mustargen was used during pregnancy. Some of the reported birth defects have included:
 
  • Missing toes
  • Bowing of the tibia (the shinbone)
  • Bleeding in the brain
  • Abnormally formed kidneys.
 
Women of childbearing potential should use an effective form of birth control to avoid becoming pregnant during Mustargen treatment. Talk to your healthcare provider about the best forms of birth control to use during your treatment.
 
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Mustargen Drug Information

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