Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Heart problems, such as congestive heart failure
  • Bone marrow problems
  • Low blood cell counts
  • Anemia
  • Frequent infections, or currently have an infection
  • Had cancer treatment or radiation treatment in the past
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Mitoxantrone to learn more, including information on who should not use the drug.)

How Does It Work?

Mitoxantrone works by damaging DNA. It does this by causing DNA strands to "cross-link" and to break. Cross-linking occurs when the strands bind to each other and become linked. The linked strands are unable to uncoil and separate, which is necessary for the DNA to make copies of itself. Mitoxantrone also blocks the action of an enzyme that helps repair damaged DNA.
When DNA is damaged and cannot make copies of itself, cells cannot divide and multiply. This causes the cells to die. Mitoxantrone can cause cell death in cells that are rapidly multiplying, as well as in cells that are not multiplying. Generally, cancer cells multiply more rapidly than healthy cells.
Mitoxantrone also prevents B-cells, T-cells, and macrophages from rapidly multiplying. These cells are thought to be involved in the immune response that causes the attack on myelin in people with MS
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Mitoxantrone Drug Information

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