Leukemia Home > Vincristine Dosage
Given as an injection into a vein, vincristine is administered by a healthcare provider in a healthcare setting once a week. The recommended dosage of vincristine will depend on your age, height, weight, and various other factors. If you have liver problems or develop dangerous side effects with this drug, you may need a lower amount.
The dose of vincristine sulfate (Vincasar PFS®) your healthcare provider recommends will vary, depending on a number of factors, such as:
- Your age
- Your height and weight
- How you tolerate the medication
- Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Like many chemotherapy medicines, vincristine doses are usually based on body surface area, which is normally calculated using your height and weight. Amounts based on body surface area are written as milligrams per meter squared (mg per m2).
The usual recommended dosage of vincristine for the treatment of cancer in adults is 1.4 mg per m2 once a week. A typical dosage for cancer treatment in adults is 2 mg weekly. There is no widely accepted maximum vincristine dose in adults.
The usual recommended dosage for children who weigh more than 10 kg (22 lbs) is 1.5 mg to 2 mg per m2 once a week. Children who weigh 10 kg (22 lbs) or less are generally started on vincristine 0.5 mg per kg (about 0.23 mg per lb) once a week. Amounts are then increased based on how well the medication is tolerated. Some experts recommend a maximum of 2 mg per dose for children.
People who have liver disease may need to be treated with lower vincristine doses. Your healthcare provider may also reduce your amount if you experience potentially serious or severe side effects.