Leukemia Home > Tasigna Drug Interactions
Live vaccines are vaccines that contain live viruses or bacteria. If you receive a live vaccine while taking Tasigna, you might become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people taking Tasigna. Talk to your healthcare provider before receiving a vaccination or immunization while taking this medication.
Tasigna can cause a certain change in the heart rhythm known as QT prolongation. Taking Tasigna with other medications that may cause QT prolongation can increase your risk for this potentially life-threatening problem. Your healthcare provider may need to monitor you for this problem if you take Tasigna with another QT-prolonging medication.
Combining Tasigna with natalizumab may increase your risk for developing infections, including potentially serious infections. It is generally recommended that these medications not be taken together.
P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body, so they can be excreted through the urine or feces. Pgp helps remove Tasigna from the body. Certain medications known as Pgp inhibitors decrease the activity of Pgp.
Taking Tasigna with one of these Pgp inhibitors causes Tasigna to be removed from the body more slowly, potentially increasing Tasigna blood levels and increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take Tasigna with a Pgp inhibitor.