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CYP 3A4 Inhibitor Medications
The liver breaks down Tasigna using enzymes known as CYP 3A4 enzymes. Certain medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining Tasigna with one of these CYP 3A4 inhibitors may increase the level of Tasigna in your bloodstream, potentially increasing your risk for serious side effects.
It is generally recommended that Tasigna not be combined with strong CYP 3A4 inhibitors. If these medicines are taken together, your healthcare provider may choose to give you a lower Tasigna dose.
Tasigna may increase the level of dabigatran in your blood, potentially increasing your risk for bleeding. Your healthcare provider may need to lower your dabigatran dose if you take it with Tasigna.
Tasigna may be less effective if taken with echinacea. Do not take these medications together unless your healthcare provider tells you otherwise.
Tasigna may increase the level of everolimus in your blood, potentially increasing your risk for everolimus side effects. Your healthcare provider may need to lower your everolimus dose if you take these medications together.
H2 blockers decrease the amount of Tasigna absorbed from the stomach into the bloodstream. This could make Tasigna less effective. The best way to handle this interaction is to take your H2 blocker two hours after your Tasigna dose, which should be 10 hours before your next Tasigna dose, since this medication is taken every 12 hours.
Combining leflunomide and Tasigna may increase your risk for blood cell problems, including abnormally low red blood cells, white blood cells, and platelets. Your healthcare provider will monitor you for these side effects during treatment.