If you have a type of cancer called acute myeloid leukemia (AML), your healthcare provider may prescribe Tabloid. This medication is available as a tablet that is taken once or twice a day; your exact dosage will be based on your height, weight, and various other factors. Side effects can include infections, bleeding, and anemia.
What Is Tabloid?
Tabloid® (thioguanine) is a prescription medication approved for the treatment of acute nonlymphocytic leukemia, a type of cancer of the blood and bone marrow. Acute nonlymphocytic leukemia is more commonly known as acute myeloid leukemia, or acute myelogenous leukemia (AML). Tabloid is normally given as part of a combination treatment that includes other medicines.
Tabloid belongs to a group of medicines called purine analogs. The active ingredient in the medication is thioguanine. Healthcare providers may also refer to it as 6-thioguanine, or simply TG.
Tabloid is made by DSM Pharmaceuticals, Inc., for GlaxoSmithKline.
In studies, Tabloid has been shown to help people with AML achieve remission when used as part of combination treatment. In one study, 59 percent of children with AML who had not been previously treated went into remission when given Tabloid in combination with other medicines, including prednisone, cytarabine (DepoCyt®), cyclophosphamide (Cytoxan®), and vincristine (Vincasar PFS®). The children stayed in remission for about 11.5 months.
In another study, 53 percent of adults with AML who had not received previous treatment achieved remission when given Tabloid in combination with cytarabine. Remission lasted about 8.8 months.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Tabloid [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2009 June.
Thioguanine. Drug Facts and Comparisons. Drug Facts and Comparisons 4.0 [online]. 2012. Available from Wolters Kluwer Health, Inc. Accessed October 27, 2012.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed October 27, 2012.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Hazardous Substances Data Bank (HSDB). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. Accessed October 27, 2012.
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