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Synribo Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Synribo is combined with any of the drugs listed above.
 
Medications That Thin the Blood
Synribo can lower blood platelet levels. Medications that thin the blood, such as anticoagulants, aspirin, and NSAIDs, should not be taken with Synribo if blood platelet counts are extremely low, as they may increase the risk of dangerous bleeding. Your healthcare provider will monitor your platelet counts during treatment. Check with your healthcare provider before taking a medicine that thins the blood to make sure it is safe to do so. 
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove Synribo from the body, and medications known as Pgp inducers increase the activity of Pgp.
 
Taking Synribo with one of these drugs may cause Synribo to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you use Synribo with a Pgp inducer to make sure it is working for you.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove Synribo from the body, and medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking Synribo with one of these drugs may cause Synribo to be removed more slowly, potentially increasing the amount of Synribo in your body and your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you use these medicines together.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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