Leukemia Home > Rituxan Dosage

Various factors will affect the dose of Rituxan you are prescribed, such as the medical condition being treated and your height and weight. This product comes in injectable form and is administered intravenously by your healthcare provider. If anything seems abnormal during your infusion, let your healthcare provider know right away in case it is an infusion reaction.

An Introduction to Dosing for Rituxan

The dose of Rituxan® (rituximab) your healthcare provider recommends may vary, depending on several factors, such as:
  • The medical condition being treated
  • Your height and weight
  • Other medical conditions you may have
  • Other medications you are taking.
As is always the case, do not adjust your dosing schedule by missing or canceling doses unless your healthcare provider specifically tells you to do so.

Recommended Rituxan Dosage

For cancer treatment, your healthcare provider will base your Rituxan dose on your body surface area, which is calculated using your height and weight. The dosage will vary, depending on your particular treatment regimen, as well as the particular type of cancer being treated.
For treating rheumatoid arthritis, the standard Rituxan dosage is two 1000-mg infusions, separated by two weeks. This can be repeated every 16 to 24 weeks as necessary. For this condition, Rituxan is almost always used in combination with methotrexate (Rheumatrex®, Trexall®).
For treating Wegener's granulomatosis (WG) or microscopic polyangiitis (MPA), the dose is calculated using your body surface area and is given once a week for four weeks. Glucocorticoids (such as methylprednisolone or prednisone) are used in combination with Rituxan for these conditions.
No matter what medical condition Rituxan is being used to treat, it is essential that your healthcare provider start your IV at a very slow drip and increase it only as you tolerate the drug. Rituxan often causes "infusion reactions," which can range from mild to lethal (see Rituxan Side Effects for more information).
In addition, you should be "premedicated" before each dose of Rituxan with certain medications (usually acetaminophen, an antihistamine, and often a steroid) to help limit the chance and severity of infusion reactions.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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