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Using Mitoxantrone to Treat Hormone-Refractory Prostate Cancer

Prostate cancer develops in the prostate, a gland that is part of the male reproductive system. The prostate is located just beneath the bladder. It secretes much of the liquid portion of semen.
In general, prostate cancer is slow-growing. Because of this, symptoms may not be present for years. By the time they do occur, the cancer may have spread (metastasized) throughout the body. Prostate cancer that has spread to other areas is called metastatic prostate cancer. It is also referred to as advanced prostate cancer.
Several different treatments are available for men with prostate cancer (see Prostate Cancer Treatment). The specific option chosen depends largely on how far the cancer has progressed, the symptoms a man is experiencing, and a man's overall health. Metastatic prostate cancer is usually treated with hormonal therapy, which can relieve painful or distressing symptoms and slow down the progression of the disease.
Most of the time, prostate cancer responds well to hormone therapy, at least initially. However, in time, most prostate cancers grow despite hormone therapy. Prostate cancer that no longer responds to hormone therapy is referred to as hormone-refractory prostate cancer.
Mitoxantrone is a type of chemotherapy approved to treat people with pain related to advanced hormone-refractory prostate cancer. It is used in combination with corticosteroid medications, such as prednisone.

Mitoxantrone Use for Acute Nonlymphocytic Leukemia

Leukemia is a type of cancer of the blood cells. There are actually many different types of leukemia. They are generally grouped by how quickly the disease develops and gets worse, as well as which blood cells are affected (see Types of Leukemia for more information).
Acute nonlymphocytic leukemia (ANLL), also referred to as acute myeloid leukemia, is a rapidly progressing form of leukemia that affects a type of blood cell known as myeloid cells. Myeloid cells are blood cells that are not lymphocytes.
Mitoxantrone is approved for the initial treatment of adults with ANLL. It is used in combination with other ANLL medications, and is often used with a chemotherapy medicine called cytarabine (Depocyt®).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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