Leukemia Home > Leukeran and Arthritis

In some cases, a healthcare provider may prescribe Leukeran® (chlorambucil) to treat rheumatoid arthritis. However, this is an "off-label" (unapproved) use for the drug.
As a type of alkylating agent, Leukeran works by interfering with DNA replication, which is a process necessary for cells to copy themselves and divide. This causes cell death.
(To learn more about taking this medicine for arthritis or other uses, click Leukeran Uses. This full-length article describes approved and unapproved uses for the medication, as well as an explanation of how it works and whether it is safe for use in children.)
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Last reviewed by: Kristi Monson, PharmD;
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