Leukemia Home > Fludara Drug Interactions
The following sections explain in detail the potentially negative reactions that can occur when Fludara is combined with any of the drugs listed above.
Combining Fludara with amphotericin B could increase your risk for amphotericin B side effects, including kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
Certain Immunosuppressant Medications
Combining Fludara with other medicines that suppress the immune system could cause extremely low blood cell counts, increasing the risk for side effects, such as anemia, infections, and bleeding problems. Fludara should not be used in combination with certain immunosuppressants, while other combinations will require close monitoring.
Using clozapine and Fludara together may increase the risk for dangerously low white blood cell counts and potentially life-threatening infections. Talk to your healthcare provider before taking clozapine during Fludara treatment. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
Echinacea may decrease the effectiveness of Fludara. Do not take echinacea during Fludara treatment without your healthcare provider's approval.
Imatinib can decrease blood levels of Fludara, potentially decreasing the drug's effectiveness. To reduce the risk for this interaction, it is recommended that imatinib be stopped at least five days before Fludara treatment. Talk to your healthcare provider about this potential interaction before you receive Fludara if you are currently taking imatinib.
Live vaccines are vaccines that contain live viruses or bacteria. If you receive a live vaccine during Fludara treatment, you could become infected with the virus or bacteria used to make the vaccine. Also, live vaccines may be less effective in people receiving Fludara. You should not receive a live vaccine during Fludara treatment.
Taking pentostatin in combination with Fludara may increase the risk for life-threatening lung damage. These medications should not be used together.
Combining roflumilast with Fludara could increase your risk for developing an infection. Talk to your healthcare provider about this potential interaction before using these medicines together.
Fludara may decrease the effectiveness of sipuleucel-T. Talk to your healthcare provider about this potential interaction before using these medicines together. If you use these medicines together, your healthcare provider may need to monitor you more closely to make sure you are adequately responding to sipuleucel-T.