Leukemia Home > Clolar Drug Interactions
The following sections explain in detail the potentially negative interactions that can occur when Clolar is combined with any of the drugs listed above.
Combining amphotericin B with chemotherapy medicines like Clolar may increase the risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
Certain Biologic and Immunologic Medications
Using Clolar with other drugs that suppress the immune system, such as certain biologic and immunologic medications, could increase your risk for potentially serious side effects, including low blood cell counts, infections, anemia, and bleeding problems. It is recommended that Clolar not be used in combination with some biologic and immunologic medicines, while other combinations will require careful monitoring.
Taking clozapine with Clolar may increase the risk for dangerously low white blood cells and potentially serious infections. Talk to your healthcare provider before using these medicines together. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
Clolar may cause your body to absorb less digoxin from the gastrointestinal (GI) tract, which could decrease the level of digoxin in your bloodstream. This interaction is thought to only be a potential problem with digoxin tablets, as opposed to other forms of digoxin, such as the solution (liquid). Your healthcare provider may choose to monitor your response to digoxin more closely if you use these drugs together.
Clolar may be less effective if it is used in combination with echinacea. Do not use these medications together without your healthcare provider's approval.
Live vaccines contain live viruses or bacteria. If you receive a live vaccine while using Clolar, you might become infected with the virus or bacteria. Also, live vaccines may be less effective in people receiving Clolar. In general, people who are undergoing chemotherapy treatment are advised to not receive a live vaccination. Talk to your healthcare provider before receiving a vaccination or immunization during chemotherapy treatment.
Medications That May Cause Kidney Damage
The manufacturer of Clolar recommends that medications with the potential to damage the kidneys not be used during the five-day Clolar treatment period. Many medications are associated with potential kidney damage. Therefore, you should ask your healthcare provider about any particular medication you are considering taking, including prescription and nonprescription medicines.
Medications That May Cause Liver Damage
The manufacturer of Clolar recommends that medications with the potential to damage the liver not be used during the five-day treatment period. Many medications are associated with potential liver damage. Therefore, you should ask your healthcare provider about any particular medication you are considering taking, including prescription and nonprescription drugs.
Combining roflumilast with Clolar may further increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before using these medicines together.
Clolar could decrease the effectiveness of sipuleucel-T. This is because sipuleucel-T is thought to work by stimulating the body's immune system, while Clolar decreases the activity of the immune system. Talk to your healthcare provider about this possible interaction before using these medicines together.
Chemotherapy medicines, such as Clolar, have been reported to both increase and decrease the effects of warfarin. If you take warfarin during Clolar treatment, your healthcare provider may need to monitor your prothrombin time ("protime" or PT) and international normalized ratio (INR) more closely than usual and adjust your warfarin dosage if needed.