Busulfex comes as an injection that is given intravenously to help people prepare for a stem cell transplant. This prescription medicine is specifically designed for people who have chronic myelogenous leukemia. It is given four times a day for four days. Most people who receive this product will develop some type of side effect, such as nausea, infections, and anemia.
Busulfex is manufactured by Ben Venue Labs, Inc., and distributed by Otsuka America Pharmaceutical, Inc.
How Does Busulfex Work?
Busulfex is part of a group of medications called alkylating agents. In general, alkylating agents work by causing strands of DNA to bond to each other and become linked (this is known as "cross-linking"). The linked strands cannot uncoil and separate, which is necessary for the DNA to replicate. Because DNA replication is essential for cells to grow and multiply, Busulfex may prevent cancer cells from growing and multiplying.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Busulfex [package insert]. Rockville, MD: Otsuka America Pharmaceutical, Inc.;2011 April.
Busulfan. Drug Facts and Comparisons. Drug Facts and Comparisons 4.0 [online]. 2012. Available from Wolters Kluwer Health, Inc. Accessed September 10, 2012.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed September 10, 2012.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed September 10. 2012.
National Library of Medicine (US). Hazardous Substances Data Bank (HSDB). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. Accessed September 10, 2012.
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