Leukemia Home > Cancer and Busulfan

Approved to treat chronic myelogenous leukemia, busulfan (Myleran®) tablets are taken once a day until certain blood cell counts return to normal. This prescription chemotherapy drug is approved for use in adults and children.
Busulfan is a type of alkylating agent and works by preventing DNA strands from separating, which is necessary for them to replicate. As a result, this drug can help prevent cancer cells from growing and multiplying.
On occasion, a healthcare provider may prescribe busulfan to treat other conditions, such as ovarian cancer, thrombocytosis, and myelofibrosis; however, these are unapproved ("off-label") uses for the medication.
(Click What Is Busulfan Used For? to learn more about using this chemotherapy drug to treat chronic myelogenous leukemia and other conditions.)
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Last reviewed by: Kristi Monson, PharmD;
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