Leukeran and Pregnancy

Women who are undergoing treatment with Leukeran (chlorambucil) should be aware of the potential risks this drug may pose to an unborn child. Leukeran is a pregnancy Category D medicine because it appeared to cause defects of the urinary and reproductive systems when given to pregnant animals. This medicine should only be taken if the benefits to the mother outweigh the risks to the fetus.

Can Pregnant Women Take Leukeran?

Leukeran® (chlorambucil) is a prescription medication used in the treatment of chronic lymphocytic leukemia and lymphoma. It is considered a pregnancy Category D medication because it may cause harm to an unborn child if taken during pregnancy.

What Is Pregnancy Category D?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category D is a classification given to medicines that have been shown to present a risk to the fetus in studies of pregnant women but may still offer benefits that outweigh the risks the drug presents. A pregnancy Category D medicine may still be given to a pregnant woman if her healthcare provider believes that the benefits to the woman outweigh the possible risks to her unborn child.
Leukeran has not been adequately studied in pregnant women. However, in animal studies, the drug caused defects of the urinary and reproductive systems (including the complete absence of a kidney) in the offspring when given to pregnant rats. In addition, there have been reports of children born without kidneys to women who took Leukeran during the first trimester of pregnancy.
It should also be noted that Leukeran may cause fertility problems in both men and women. There is a possibility that infertility from Leukeran could be irreversible even after the medicine is stopped.
Pregnancy and Pain

Leukeran Chemotherapy Information

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