If you have certain types of leukemia, your healthcare provider may prescribe Iclusig. This medication is available as a tablet that is taken once daily. Your dosage will be based on how you respond to the medicine, other medical conditions you may have, and various other factors. Side effects can include fatigue, headaches, and a rash.


What Is Iclusig?

Iclusig® (ponatinib) is a prescription medication approved for the treatment of leukemia, cancer of the blood cells and bone marrow. It is specifically approved to treat the following types of leukemia:
  • Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL)
  • Chronic myeloid leukemia (CML).
Iclusig is reserved for use in people who no longer benefit from, or who cannot tolerate, certain other types of treatment.
(Click Iclusig Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Iclusig is made by ARIAD Pharmaceuticals, Inc.

How Does Iclusig Work?

Iclusig belongs to a group of medicines known as tyrosine kinase inhibitors. Tyrosine kinases are proteins found in the body that control cell function, including cell growth. Iclusig works by blocking the signal of certain tyrosine kinases, including but not limited to:
  • A mutated kinase known as T315I mutant ABL
  • A kinase that is resistant to treatment with other tyrosine kinase inhibitors.
By inhibiting the activity of T315I mutant ABL and other kinases, Iclusig slows down or stops the production of the abnormal blood cells.
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