Iclusig Overdose

Some of the potential complications that may occur as a result of an overdose with Iclusig (ponatinib) include chest pain, pneumonia, and irregular heart rhythms. The specific effects, however, will depend on how much of the drug was taken and a number of other factors. Treatment will likely involve administering certain medications, pumping the stomach, and providing supportive care.

Can You Take Too Much Iclusig?

Iclusig® (ponatinib) is a prescription medication used to treat certain adults with leukemia, a cancer of the blood cells and bone marrow. As with most medications, it is possible to take too much Iclusig.
The specific effects of an overdose would likely vary, depending on a number of factors, including the Iclusig dosage and whether it was taken with any other medications or substances.

Effects of an Overdose

In the few reported cases of an Iclusig overdose, the following problems were reported:
  • Pneumonia
  • Irregular heart rhythms (arrhythmias)
  • Abnormal fluid accumulation around the heart (pericardia effusion)
  • Body-wide inflammatory reactions
  • Fatigue
  • Chest pain.

Treatment Options for an Iclusig Overdose

If the overdose was recent, a healthcare provider may administer activated charcoal or "pump the stomach" to help reduce the amount of medication absorbed into the bloodstream.
Treatment will also likely involve supportive care, which consists of treating the symptoms that occur as a result of the overdose. Supportive care for an Iclusig overdose may include:
  • Medications to treat vomiting and diarrhea
  • Fluids given through a needle inserted into a vein (intravenous, or IV, fluids)
  • Close monitoring of blood cell counts.
Seek immediate medical attention if you believe you or someone else may have taken too much Iclusig.
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