Iclusig Drug Interactions

Iclusig Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Iclusig is combined with any of the drugs listed above.
 
Antacids
Stomach acid is needed to absorb Iclusig from the stomach into the bloodstream. Medicines that reduce stomach acid can reduce Iclusig blood levels. You can take Iclusig with antacids, just make sure to separate the doses of each product by at least two hours.
 
CYP 3A4 Inducer Medications
The liver breaks down Iclusig using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Iclusig with one of these drugs may decrease the amount of Iclusig in your body, potentially making it less effective. Iclusig should not be taken with certain CYP 3A4 inducers. Your healthcare provider can tell you which medicines are safe to take.
 
CYP 3A4 Inhibitor Medications
The liver breaks down Iclusig using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Iclusig with one of these drugs may increase the amount of Iclusig in your body, increasing your risk for serious side effects. Iclusig should not be taken with certain CYP 3A4 inhibitors. Your healthcare provider can tell you which medicines are safe to take.
 
H2 Blockers
Iclusig is best absorbed in the presence of stomach acid. Medications that reduce stomach acid, including H2 blockers, may decrease the amount of Iclusig absorbed from the stomach into the bloodstream. If you must take an H2 blocker, make sure to separate the doses of the two products by several hours (at least two, although longer is probably preferable).
 
Proton Pump Inhibitors (PPIs)
Stomach acid is needed to absorb Iclusig from the stomach into the bloodstream. Medicines that reduce stomach acid, including PPIs, can reduce Iclusig blood levels. Do not take these drugs together.
 
P-gp Substrates or ABCG2 Substrates
P-gp and ABCG2 are natural proteins that help remove substances such as medications from the cells in the body. Iclusig inhibits these proteins and may interact with drugs that are affected by these proteins (such drugs are known as "substrates" of these proteins). Check with your healthcare provider before taking Iclusig with any of these medications.
 
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