Leukemia Channel
Topics
Medications
Quicklinks
Related Channels
Gleevec Drug Interactions
Combining Tylenol, colchicine, or other drugs with Gleevec can lead to potentially serious interactions. As a result, the effectiveness of certain medications may be reduced or you may be at a higher risk of side effects. To help avoid complications, tell your healthcare provider about any medications, vitamins, or herbal supplements you are taking.
An Overview of Interactions With Gleevec
Gleevec® (imatinib mesylate) can potentially react with a number of other medications. Some of the drugs that may interact with Gleevec include but are not limited to:- Acetaminophen (Tylenol®)
- Alfuzosin (Uroxatral®)
- Almotriptan (Axert®)
- Budesonide capsules (Entocort EC®) and budesonide inhalation (Pulmicort®)
- Certain statin medications, such as:
- Lovastatin (Altoprev®, Mevacor®) or combination medications that contain lovastatin (Advicor®)
- Simvastatin (Zocor®) or combination medications that contain simvastatin (Vytorin® or Simcor®)
- Colchicine (Colcrys®)
- CYP 3A4 inducer medications, such as:
- Aminoglutethimide (Cytadren®)
- Bosentan (Tracleer®)
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Dexamethasone (Decadron®, Dexpak®, Maxidex®)
- Efavirenz (Sustiva®)
- Efavirenz, emtricitabine, and tenofovir (Atripla®)
- Etravirine (Intelence™)
- Fosphenytoin (Cerebyx®)
- Nafcillin
- Nevirapine (Viramune®)
- Oxcarbazepine (Trileptal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Phenytoin (Dilantin®, Phenytek®)
- Primidone (Mysoline®)
- Rifabutin (Mycobutin®)
- Rifampin (Rifadin®)
- Rifapentine (Priftin®)
- St. John's wort
- CYP 3A4 inhibitor medications, such as:
- Amprenavir (Agenerase®)
- Atazanavir (Reyataz®)
- Clarithromycin (Biaxin®)
- Conivaptan (Vaprisol®)
- Crizotinib (Xalkori®)
- Darunavir (Prezista®)
- Delavirdine (Rescriptor®)
- Erythromycin
- Fluconazole (Diflucan®)
- Fosamprenavir (Lexiva®)
- Indinavir (Crixivan®)
- Isoniazid
- Itraconazole (Sporanox®)
- Ketoconazole (Nizoral®)
- Lopinavir and ritonavir (Kaletra®)
- Miconazole
- Nefazodone (Serzone®)
- Nelfinavir (Viracept®)
- Nicardipine (Cardene®)
- Posaconazole (Noxafil®)
- Quinidine
- Ritonavir (Norvir®)
- Saquinavir (Fortovase®, Invirase®)
- Telaprevir (INCIVEK™)
- Telithromycin (Ketek®)
- Voriconazole (VFEND®)
- Denosumab (Prolia®)
- Echinacea
- Eplerenone (Inspra®)
- Everolimus (Afinitor®, Zortress®)
- Fentanyl (Abstral®, Actiq®, Duragesic®, Fentora®, Lazanda®, Onsolis®, Subsys®)
- Fesoterodine (Toviaz®)
- Fluticasone (Flovent®)
- Leflunomide (Arava®)
- "Live" vaccinations, such as:
- Chickenpox vaccine (varicella vaccine)
- FluMist® (the nasal vaccine for influenza; the injected vaccine is not live)
- MMR vaccine (measles, mumps, rubella vaccine)
- Polio vaccine
- Rotavirus vaccine
- Smallpox vaccine
- Yellow fever vaccine
- BCG vaccine (used in some countries for tuberculosis)
- Lurasidone (Latuda®)
- Natalizumab (Tysabri®)
- P-glycoprotein inducers, such as:
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Dexamethasone (Decadron®)
- Doxorubicin (Adriamycin®, Doxil®)
- Nefazodone (Serzone®)
- Prazosin (Minipress®)
- Rifampin (Rifadin®)
- St. John's wort
- Tipranavir (Aptivus®)
- Trazodone (Desyrel®) and trazodone ER (Oleptro™)
- Vinblastine
- P-glycoprotein inhibitors, such as:
- Amiodarone (Cordarone®, Pacerone®)
- Atorvastatin (Lipitor®) or combination medications that contain atorvastatin (Caduet®, Liptruzet™)
- Carvedilol (Coreg®, Coreg CR®)
- Clarithromycin (Biaxin®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Darunavir (Prezista®)
- Dipyridamole (Persantine®, also found in Aggrenox®)
- Dronedarone (Multaq®)
- Erythromycin
- Grapefruit juice
- Itraconazole (Sporanox®)
- Ketoconazole (Nizoral®)
- Lapatinib (Tykerb®)
- Lopinavir and ritonavir (Kaletra®)
- Mefloquine (Lariam®)
- Nelfinavir (Viracept®)
- Nicardipine (Cardene®)
- Nilotinib (Tasigna®)
- Progesterone
- Propranolol (Inderal®, Inderal LA®, InnoPran XL®, also found in Inderide®)
- Quinidine
- Ranolazine (Ranexa®)
- Reserpine
- Ritonavir (Norvir®, also found in Kaletra®)
- Saquinavir (Invirase®)
- Sunitinib
- Tacrolimus (Prograf®, Protopic®)
- Tamoxifen (Nolvadex®)
- Telaprevir (INCIVEK™)
- Verapamil (Calan®, Calan SR®, Covera-HS®, Isoptin SR®, Verelan®, Verelan PM®)
- Pimecrolimus (Elidel®)
- Rivaroxaban (Xarelto®)
- Salmeterol (Serevent®)
- Tacrolimus ointment (Protopic®)
- Tamsulosin (Flomax®)
- Tolvaptan (Samsca®)
- Topotecan (Hycamtin®)
- Trastuzumab (Herceptin®).
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD