Gleevec Drug Interactions

Combining Tylenol, colchicine, or other drugs with Gleevec can lead to potentially serious interactions. As a result, the effectiveness of certain medications may be reduced or you may be at a higher risk of side effects. To help avoid complications, tell your healthcare provider about any medications, vitamins, or herbal supplements you are taking.

• Acetaminophen (Tylenol^®)
• Alfuzosin (Uroxatral^®)
• Almotriptan (Axert^®)
• Budesonide capsules (Entocort EC^®) and budesonide inhalation (Pulmicort^®)
• Certain statin medications, such as:
   
  • Lovastatin (Altoprev^®, Mevacor^®) or combination medications that contain lovastatin (Advicor^®)
  • Simvastatin (Zocor^®) or combination medications that contain simvastatin (Vytorin^® or Simcor^®)

• Colchicine (Colcrys^®)
• CYP 3A4 inducer medications, such as:
   
  • Aminoglutethimide (Cytadren^®)
  • Bosentan (Tracleer^®)
  • Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
  • Dexamethasone (Decadron^®, Dexpak^®, Maxidex^®)
  • Efavirenz (Sustiva^®)
  • Efavirenz, emtricitabine, and tenofovir (Atripla^®)
  • Etravirine (Intelence™)
  • Fosphenytoin (Cerebyx^®)
  • Nafcillin
  • Nevirapine (Viramune^®)
  • Oxcarbazepine (Trileptal^®)
  • Pentobarbital (Nembutal^®)
  • Phenobarbital (Luminal^®)
  • Phenytoin (Dilantin^®, Phenytek^®)
  • Primidone (Mysoline^®)
  • Rifabutin (Mycobutin^®)
  • Rifampin (Rifadin^®)
  • Rifapentine (Priftin^®)
  • St. John's wort

• CYP 3A4 inhibitor medications, such as:
   
  • Amprenavir (Agenerase^®)
  • Atazanavir (Reyataz^®)
  • Clarithromycin (Biaxin^®)
  • Conivaptan (Vaprisol^®)
  • Crizotinib (Xalkori^®)
  • Darunavir (Prezista^®)
  • Delavirdine (Rescriptor^®)
  • Erythromycin
  • Fluconazole (Diflucan^®)
  • Fosamprenavir (Lexiva^®)
  • Indinavir (Crixivan^®)
  • Isoniazid
  • Itraconazole (Sporanox^®)
  • Ketoconazole (Nizoral^®)
  • Lopinavir and ritonavir (Kaletra^®)
  • Miconazole
  • Nefazodone (Serzone^®)
  • Nelfinavir (Viracept^®)
  • Nicardipine (Cardene^®)
  • Posaconazole (Noxafil^®)
  • Quinidine
  • Ritonavir (Norvir^®)
  • Saquinavir (Fortovase^®, Invirase^®)
  • Telaprevir (INCIVEK™)
  • Telithromycin (Ketek^®)
  • Voriconazole (VFEND^®)

• Denosumab (Prolia^®)
• Echinacea
• Eplerenone (Inspra^®)
• Everolimus (Afinitor^®, Zortress^®)
• Fentanyl (Abstral^®, Actiq^®, Duragesic^®, Fentora^®, Lazanda^®, Onsolis^®, Subsys^®)
• Fesoterodine (Toviaz^®)
• Fluticasone (Flovent^®)
• Leflunomide (Arava^®)
• "Live" vaccinations, such as:
   
  • Chickenpox vaccine (varicella vaccine)
  • FluMist^® (the nasal vaccine for influenza; the injected vaccine is not live)
  • MMR vaccine (measles, mumps, rubella vaccine)
  • Polio vaccine
  • Rotavirus vaccine
  • Smallpox vaccine
  • Yellow fever vaccine
  • BCG vaccine (used in some countries for tuberculosis)

• Lurasidone (Latuda^®)
• Natalizumab (Tysabri^®)
• P-glycoprotein inducers, such as:
   
  • Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
  • Dexamethasone (Decadron^®)
  • Doxorubicin (Adriamycin^®, Doxil^®)
  • Nefazodone (Serzone^®)
  • Prazosin (Minipress^®)
  • Rifampin (Rifadin^®)
  • St. John's wort
  • Tipranavir (Aptivus^®)
  • Trazodone (Desyrel^®) and trazodone ER (Oleptro™)
  • Vinblastine

• P-glycoprotein inhibitors, such as:
   
  • Amiodarone (Cordarone^®, Pacerone^®)
  • Atorvastatin (Lipitor^®) or combination medications that contain atorvastatin (Caduet^®, Liptruzet™)
  • Carvedilol (Coreg^®, Coreg CR^®)
  • Clarithromycin (Biaxin^®)
  • Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
  • Darunavir (Prezista^®)
  • Dipyridamole (Persantine^®, also found in Aggrenox^®)
  • Dronedarone (Multaq^®)
  • Erythromycin
  • Grapefruit juice
  • Itraconazole (Sporanox^®)
  • Ketoconazole (Nizoral^®)
  • Lapatinib (Tykerb^®)
  • Lopinavir and ritonavir (Kaletra^®)
  • Mefloquine (Lariam^®)
  • Nelfinavir (Viracept^®)
  • Nicardipine (Cardene^®)
  • Nilotinib (Tasigna^®)
  • Progesterone
  • Propranolol (Inderal^®, Inderal LA^®, InnoPran XL^®, also found in Inderide^®)
  • Quinidine
  • Ranolazine (Ranexa^®)
  • Reserpine
  • Ritonavir (Norvir^®, also found in Kaletra^®)
  • Saquinavir (Invirase^®)
  • Sunitinib
  • Tacrolimus (Prograf^®, Protopic^®)
  • Tamoxifen (Nolvadex^®)
  • Telaprevir (INCIVEK™)
  • Verapamil (Calan^®, Calan SR^®, Covera-HS^®, Isoptin SR^®, Verelan^®, Verelan PM^®)

• Pimecrolimus (Elidel^®)
• Rivaroxaban (Xarelto^®)
• Salmeterol (Serevent^®)
• Tacrolimus ointment (Protopic^®)
• Tamsulosin (Flomax^®)
• Tolvaptan (Samsca^®)
• Topotecan (Hycamtin^®)
• Trastuzumab (Herceptin^®).