Fludara Uses

How Does It Work?

Fludara works by blocking the action of certain naturally occurring enzymes that are necessary for DNA to make a copy of itself (known as DNA replication). Because DNA replication is necessary for cells to divide, Fludara can slow down the growth of cancer cells and cause them to die.
Fludara is not itself active against cancer cells. Instead, the body rapidly converts the drug into an active form within minutes after each dose is given.

Is It Safe for Children to Use Fludara?

Fludara is not approved for use in children. In clinical studies, the drug was not shown to be effective against childhood cancers, including acute leukemia. Talk to your child's healthcare provider about the risks and benefits of using Fludara in children.

Can Older Adults Use It?

Older adults can use Fludara. However, people with kidney disease are usually given lower Fludara doses. Because kidney function tends to decline with age, older adults may have decreased kidney function and, therefore, may need to be treated with lower doses of Fludara. Older adults should receive blood tests to evaluate their kidney function before starting Fludara treatment.

Off-Label Uses for Fludara

On occasion, your healthcare provider may recommend this medication for treating something other than hairy cell leukemia. This is called an "off-label" use. Fludara may sometimes be prescribed off-label for the following uses:
  • Treatment of acute myeloid leukemia
  • Treatment of non-Hodgkin 's lymphoma
  • To prepare the body for a bone marrow transplant.
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