Phases of Chronic Myelogenous Leukemia (Cont.)

CML

Phases of Chronic Myelogenous Leukemia: Specifics

As the amount of blast cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. This may result in:
 
  • Infections
  • Anemia
  • Easy bleeding
  • Bone pain
  • Pain or a feeling of fullness below the ribs on the left side.
 
The number of blast cells in the blood and bone marrow and the severity of CML symptoms will determine the phase of the disease.
 

Phases of Chronic Myelogenous Leukemia: Chronic Phase

In chronic phase CML, 5 percent or fewer of the cells in the blood and bone marrow are blast cells.
 

Phases of Chronic Myelogenous Leukemia: Accelerated Phase

In accelerated phase CML, 6 to 30 percent of the cells in the blood and bone marrow are blast cells.
 

Phase of Chronic Myelogenous Leukemia: Blastic Phase

In blastic phase CML, more than 30 percent of the cells in the blood or bone marrow are blast cells. When tiredness, fever, and an enlarged spleen occur during the blastic phase, it is called blast crisis.
 

Phases of Chronic Myelogenous Leukemia: Relapsed CML

In relapsed CML, the number of blast cells increases after a remission.

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Written by/reviewed by: Arthur Schoenstadt, MD
Last reviewed by: Arthur Schoenstadt, MD