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Busulfex
Busulfex comes as an injection that is given intravenously to help people prepare for a stem cell transplant. This prescription medicine is specifically designed for people who have chronic myelogenous leukemia. It is given four times a day for four days. Most people who receive this product will develop some type of side effect, such as nausea, infections, and anemia.
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Busulfex® (busulfan injection) is a prescription medication approved to prepare the body for a stem cell transplant, specifically in people with chronic myelogenous leukemia (also called chronic myeloid leukemia). It is used in combination with another medication called cyclophosphamide (Cytoxan®). Busulfex is in a class of medicines known as alkylating agents.
(Click Busulfex Uses for more information on this topic, including possible off-label uses.)
Busulfex is manufactured by Ben Venue Labs, Inc., and distributed by Otsuka America Pharmaceutical, Inc.
Busulfex is part of a group of medications called alkylating agents. In general, alkylating agents work by causing strands of DNA to bond to each other and become linked (this is known as "cross-linking"). The linked strands cannot uncoil and separate, which is necessary for the DNA to replicate. Because DNA replication is essential for cells to grow and multiply, Busulfex may prevent cancer cells from growing and multiplying.
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD