Busulfex Uses

Adults who have chronic myelogenous leukemia and are about to undergo a stem cell transplant may receive Busulfex to help prepare the body for the transplant. Busulfex is used in combination with another medication called Cytoxan. This high-dose chemotherapy regimen is used before a stem cell transplant to help destroy cancer cells. It works by interrupting the way DNA replicates.

What Is Busulfex Used For?

Busulfex® (busulfan injection) is a prescription medication approved to prepare the body for a stem cell transplant in people with chronic myelogenous leukemia. It is used in combination with a medication known as cyclophosphamide (Cytoxan®).
 

What Is Chronic Myelogenous Leukemia?

Chronic myelogenous leukemia (also called chronic myeloid leukemia, chronic myelocytic leukemia, chronic granulocytic leukemia, or just CML) is a slowly progressing cancer of the blood cells. It is one of several leukemia types (see Types of Leukemia for more information on this topic).
 
Normally, the bone marrow (the spongy center of certain bones in the body) makes immature blood cells called stem cells. Blood stem cells become mature white blood cells, red blood cells, and platelets. However, in CML, too many stem cells become a type of white blood cell known as a granulocyte. These granulocytes are abnormal, and do not work like regular white blood cells.
 
As the number of abnormal granulocytes increases, they may crowd out healthy, normal blood cells. This can lead to problems such as:
 
 
 
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Busulfex Drug Information

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