Busulfex Drug Interactions

CYP 3A4 Inhibitor Medications
The liver breaks down Busulfex using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Busulfex with one of these drugs may increase the level of Busulfex in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely for side effects if you use these medicines together.
 
Echinacea
Echinacea could decrease the effectiveness of Busulfex. Talk to your healthcare provider before taking these products together.
 
Ifosfamide
Combining Busulfex with ifosfamide may increase your risk for a potentially serious bladder condition known as hemorrhagic cystitis. Hemorrhagic cystitis is associated with bladder irritation and blood in the urine. Your healthcare provider may choose to monitor you more closely, or give you other medicines to prevent hemorrhagic cystitis if you take these drugs together.
 
Itraconazole
Itraconazole may increase blood levels of Busulfex, which could increase your risk for side effects. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. It is generally recommended that people receiving chemotherapy not receive live vaccines. This is because chemotherapy medicines, including Busulfex, may increase your risk for infections, and you could become infected with the virus or bacteria used to make a live vaccine. Also, live vaccines may be less effective during chemotherapy treatment. Talk to your healthcare provider before getting a vaccination while you are using this drug.
 
Metronidazole
Metronidazole may increase blood levels of Busulfex, which could increase your risk for side effects. It is generally advised that these medicines not be used together, if at all possible. Talk to your healthcare provider before taking metronidazole during chemotherapy treatment.
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Busulfex Drug Information

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