Bosulif Drug Interactions

Bosulif Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Bosulif is combined with any of the drugs listed above.
 
Antacids
Stomach acid is needed to absorb Bosulif from the stomach into the bloodstream. Medicines that reduce stomach acid can reduce Bosulif blood levels. You can take Bosulif with antacids -- just make sure to separate the antacid and Bosulif dose by at least two hours.
 
CYP 3A4 Inducer Medications
The liver breaks down Bosulif using enzymes known as CYP 3A4 enzymes, and some medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Bosulif with one of these drugs may decrease the amount of Bosulif in your bloodstream, potentially making it less effective. Bosulif should not be taken with certain CYP 3A4 inducers. Your healthcare provider can tell you which medicines are safe to take with Bosulif.
 
CYP 3A4 Inhibitor Medications
The liver breaks down Bosulif using enzymes known as CYP 3A4 enzymes, and some medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Bosulif with one of these drugs may increase the amount of Bosulif in your bloodstream, increasing your risk for serious side effects. Bosulif should not be taken with certain CYP 3A4 inhibitors. Your healthcare provider can tell you which medicines are safe to take with Bosulif.
 
Digoxin
Bosulif may increase the level of digoxin in your bloodstream, increasing your risk for digoxin side effects. Your healthcare provider may choose to monitor your digoxin blood levels if you take these medicines together.
 
H2 Blockers
Bosulif is best absorbed in the presence of stomach acid. Medications that reduce stomach acid, such as H2 blockers, may decrease the amount of Bosulif absorbed from the stomach into the bloodstream. If you take an H2 blocker, make sure to take it at least two hours before, or two hours after, your Bosulif dose.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, including medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove Bosulif from the body. Certain other medications (known as Pgp inhibitors) decrease the activity of Pgp.
 
Taking Bosulif with one of these Pgp inhibitors causes Bosulif to be removed from the body more slowly, increasing Bosulif blood levels and increasing your risk for side effects. Bosulif should not be taken with certain Pgp inhibitors. Your healthcare provider can tell you which medicines are safe to take with Bosulif.
 
Proton Pump Inhibitors (PPIs)
Stomach acid is needed to absorb Bosulif from the stomach into the bloodstream. Medicines that reduce stomach acid, such as PPIs, can reduce Bosulif blood levels. Do not take Bosulif with a PPI.
 
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