Your healthcare provider will consider other medical conditions you may have, along with several other factors, before determining your Bosulif dosage. This chemotherapy drug comes as a tablet that is usually taken once daily. People who have problems with their liver may need a lower dosage. The tablets must be swallowed whole, and you should take each dose with food.
The dose of Bosulif® (bosutinib) your healthcare provider recommends will vary, depending on a number of factors, including:
- How you respond to the medication
- Whether you experience side effects
- Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
The standard recommended dosage of Bosulif for the treatment of chronic myelogenous leukemia (CML) is 500 mg once a day with food. Your healthcare provider may increase the amount to 600 mg once a day if you do not achieve an adequate response after 8 to 12 weeks of treatment.
You may need to stop taking Bosulif if you experience potentially serious side effects, such as severe diarrhea, low blood cell counts, or increased liver enzymes. Once your side effects improve, your healthcare provider may restart you at the same dosage or reduce the amount to Bosulif 400 mg a day, or even 300 mg a day. Doses less than 300 mg a day have not been adequately studied in clinical trials.
People with liver disease are normally given lower doses. The recommended initial Bosulif dose for people with mild-to-severe liver disease is usually 200 mg once a day. This amount is expected to be equivalent to a 500-mg dose in people without liver disease.